HIGD2A is required for assembly of the COX3 module of human mitochondrial complex IV
D. H. Hock, B. Reljic, C.-S. Ang, H. S. Mountford, A. G. Compton, M. T. Ryan, D. R. Thorburn, D. A. Stroud
This study shows HIGD2A is essential for assembling the COX3 module of human mitochondrial complex IV, leading to defects in complex IV activity and intermediate accumulation.
bioRxiv · Dec 19, 2019Biochemistry