D. A. Stroud

Deep multi-omic profiling reveals extensive mitochondrial remodeling driven by glycemia in early diabetic kidney disease

This study shows that blood glucose levels directly affect mitochondrial function and metabolism in early diabetic kidney disease, with changes in proteome, metabolome, and lipidome.

Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis

This study shows that deleting Mtfp1 in hepatocytes increases mitochondrial respiration and protects against fatty liver disease.

Fibre-specific mitochondrial protein abundance is linked to resting and post-training mitochondrial content in human muscle.

The paper examines fibre-specific mitochondrial protein abundance in human muscle before and after training, finding that most differences are linked to mitochondrial content rather than fibre-type-specific remodelling.

E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins

This study identifies MARCHF5 as a regulator of BAK apoptotic activity through ubiquitin ligase activity, independent of BH3-only proteins, and shows its role in drug resistance.

Proteomic identification and structural basis for the interaction between sorting nexin SNX17 and PDLIM family proteins

The paper identifies the structural basis of the interaction between SNX17 and PDLIM family proteins, revealing a specific PDZ binding motif and unique electrostatic contacts.

Mitochondrial COA7 is a heme-binding protein involved in the early stages of complex IV assembly.

This study identifies COA7 as a heme-binding protein essential for complex IV assembly, revealing its structure and heme-binding mechanism in mitochondrial biogenesis.

Caveolae respond to acute oxidative stress through membrane lipid peroxidation, cytosolic release of CAVIN1, and downstream regulation of NRF2

This study shows that caveolae regulate oxidative stress response by lipid peroxidation, CAVIN1 release, and NRF2 interaction, affecting cell death and regeneration.

Training-induced bioenergetic improvement in human skeletal muscle is associated with non-stoichiometric changes in the mitochondrial proteome without reorganization of respiratory chain content

The paper investigates training-induced mitochondrial adaptations in human skeletal muscle, finding non-stoichiometric changes in the proteome and challenging previous assumptions about bioenergetic improvements.

De novo macrocyclic peptides for inhibiting, stabilising and probing the function of the Retromer endosomal trafficking complex

The paper develops macrocyclic peptides that inhibit, stabilize, and probe the Retromer complex's function, showing high affinity and specificity for different subunits.

Optic Atrophy-associated TMEM126A is an assembly factor for the ND4-module of Mitochondrial Complex I

This study identifies TMEM126A as a critical assembly factor for the ND4-module of mitochondrial complex I, distinct from its paralogue TMEM126B, which assembles the ND2-module.

Cavin3 released from caveolae interacts with BRCA1to regulate the cellular stress response

This study shows cavin3 interacts with BRCA1 to regulate DNA repair and cellular stress response, with implications for cancer.

The TIM22 complex regulates mitochondrial one-carbon metabolism by mediating the import of Sideroflexins

This study identifies Sideroflexins as substrates of the TIM22 complex and shows their role in mitochondrial one-carbon metabolism, linking AGK dysfunction to Sengers syndrome.

BRAWNIN: A sORF-encoded Peptide Essential for Vertebrate Mitochondrial Complex III Assembly

The paper identifies BRAWNIN, a sORF-encoded peptide critical for vertebrate mitochondrial complex III assembly, showing its role in oxidative phosphorylation and metabolic function.

HIGD2A is required for assembly of the COX3 module of human mitochondrial complex IV

This study shows HIGD2A is essential for assembling the COX3 module of human mitochondrial complex IV, leading to defects in complex IV activity and intermediate accumulation.

Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly (MCIA) Complex Factors in the Biogenesis of Complex I

The paper identifies TMEM186 and COA1 as new components of the MCIA complex and elucidates their roles in complex I assembly.

Neuronal-specific function of hTim8a in Complex IV assembly provides insight into the molecular mechanism underlying Mohr-Tranebjaerg syndrome

This study identifies hTim8a's role in neuronal Complex IV assembly and shows how its loss causes oxidative stress and apoptosis, contributing to Mohr-Tranebjaerg syndrome.