Author

D. R. Thorburn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. E. Frazier· 3 shared D. A. Stroud· 3 shared B. Reljic· 2 shared M. T. Ryan· 2 shared A. G. Compton· 1 shared A. J. Anderson· 1 shared A. Laskowski· 1 shared A. Otake· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

A. E. Frazier

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics

T. Qaqorh, Y. Takahashi, K. Otani, I. Yazawa, Y. Nishida, Y. Fujihara, M. Honda, S. Oki, Y. Ohkawa, D. R. Thorburn, A. E. Frazier, A. Takeda, Y. Ikeda, H. Sakaguchi, T. Watanabe, , Y. Shintani

This study identifies Atf3 as a key regulator of transition from compensation to dysfunction in female mitochondrial cardiomyopathy using single-cell transcriptomics.

bioRxiv · Sep 11, 2023Cell Biology

Training-induced bioenergetic improvement in human skeletal muscle is associated with non-stoichiometric changes in the mitochondrial proteome without reorganization of respiratory chain content

C. Granata, N. J. Caruana, J. Botella, N. A. Jamnick, K. Huynh, J. Kuang, H. A. Janssen, B. Reljic, N. A. Mellett, A. Laskowski, T. L. Stait, A. E. Frazier, M. T. Coughlan, P. J. Meikle, D. R. Thorburn, , D. J. Bishop

The paper investigates training-induced mitochondrial adaptations in human skeletal muscle, finding non-stoichiometric changes in the proteome and challenging previous assumptions about bioenergetic improvements.

bioRxiv · Feb 19, 2021Cell Biology

HIGD2A is required for assembly of the COX3 module of human mitochondrial complex IV

D. H. Hock, B. Reljic, C.-S. Ang, H. S. Mountford, A. G. Compton, M. T. Ryan, D. R. Thorburn, D. A. Stroud

This study shows HIGD2A is essential for assembling the COX3 module of human mitochondrial complex IV, leading to defects in complex IV activity and intermediate accumulation.

bioRxiv · Dec 19, 2019Biochemistry

Neuronal-specific function of hTim8a in Complex IV assembly provides insight into the molecular mechanism underlying Mohr-Tranebjaerg syndrome

Y. Kang, A. J. Anderson, D. P. De Souza, C. S. Palmer, K. M. Fujihara, T. Stait, A. E. Frazier, N. J. Clemons, D. Tull, D. R. Thorburn, M. J. McConville, M. T. Ryan, D. A. Stroud, D. Stojanovski

This study identifies hTim8a's role in neuronal Complex IV assembly and shows how its loss causes oxidative stress and apoptosis, contributing to Mohr-Tranebjaerg syndrome.

bioRxiv · Aug 5, 2019 · PreprintCell Biology