Author

A. G. O'Neill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. L. Burrell· 2 shared J. M. Kollman· 2 shared A. L. Rippert· 1 shared C. Clarke· 1 shared D. Sokolov· 1 shared H. M. Shaked· 1 shared J. Molfino· 1 shared J. Quispe· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

A. L. Burrell

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2 papers

Recent·Most cited

BiochemistryJournal of Cell BiologyPeer-reviewedFeb 7, 2024

Light-sensitive phosphorylation regulates enzyme activity and filament assembly of human IMPDH1 retinal splice variants

S. J. Calise, A. G. O'Neill, A. L. Burrell…·J. M. Kollman

This paper shows phosphorylation at S477 regulates IMPDH1 filament assembly and activity, modulating GTP synthesis in retinal cells.

DOI 10.1083/jcb.202310139

humanproteomics

𝕏 PostBluesky

BiochemistrybioRxivMar 15, 2023

Point mutations in IMPDH2 which cause early-onset neurodevelopmental disorders disrupt enzyme regulation and filament structure

A. G. O'Neill, A. L. Burrell, M. Zech…·J. M. Kollman

The paper identifies two new IMPDH2 mutations linked to neurodevelopmental disorders and shows they disrupt GTP regulation and enzyme function through structural and functional analysis.

DOI 10.1016/j.jbc.2023.105012

humanstructural biology

𝕏 PostBluesky