Senescent Preosteoclast Secretome Promotes Metabolic Syndrome Associated Osteoarthritis through Cyclooxygenase 2
M. Wan, W. Su, G. Liu, B. Mohajer, J. Wang, A. Shen, W. Zhang, B. Liu, A. Guermazi, P. Gao, X. Cao, S. Demehri
This study identifies a senescent preosteoclast secretome-COX2/PGE2 axis as a driver of metabolic syndrome-associated osteoarthritis, with selective COX2 inhibitors showing therapeutic potential.
bioRxiv · May 5, 2022Cell Biology