Author

S. Demehri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Guermazi· 1 shared A. Hernandez· 1 shared A. Matsui· 1 shared A. Morita· 1 shared A. Shen· 1 shared B. Liu· 1 shared B. Mohajer· 1 shared D. G. Duda· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCell Biology

A. Guermazi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Liver fibrosis uncouples tumor control from survival after multikinase inhibitor immunotherapy in hepatocellular carcinoma

S. Morita, T. Ando, H. Kikuchi, A. Morita, T. Kobayashi, G. Birch, R. Tanaka, A. Matsui, Z. Ruan, P. Huang, Y. Cho, A. Hernandez, J. W. Lee, E. M. Coyne, S. M. Shin, , D. G. Duda

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.

bioRxiv · Oct 20, 2023 · PreprintCancer Biology

Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen

T. Hasegawa, T. Oka, H. G. Son, V. S. Oliver-Garcia, M. Azin, T. M. Eisenhaure, D. J. Lieb, N. Hacohen, S. Demehri

The paper shows that cytotoxic CD4+ T cells eliminate senescent fibroblasts by targeting HCMV-gB antigen expressed on these cells, reducing their accumulation in old skin.

bioRxiv · Mar 6, 2023Immunology

Senescent Preosteoclast Secretome Promotes Metabolic Syndrome Associated Osteoarthritis through Cyclooxygenase 2

M. Wan, W. Su, G. Liu, B. Mohajer, J. Wang, A. Shen, W. Zhang, B. Liu, A. Guermazi, P. Gao, X. Cao, S. Demehri

This study identifies a senescent preosteoclast secretome-COX2/PGE2 axis as a driver of metabolic syndrome-associated osteoarthritis, with selective COX2 inhibitors showing therapeutic potential.

bioRxiv · May 5, 2022Cell Biology

Fractional Laser Treatment Boosts Systemic Anti-Tumor Immunity in Combination with OX40 Agonist and PD-1 Blockade

M. Kawakubo, J. Glahn, Z. Tao, S. Demehri, D. Manstein

This study shows that combining fractional laser treatment with PD-1 blockade and OX40 agonist significantly reduces tumor growth and induces complete remission in mice.

bioRxiv · Nov 29, 2021 · PreprintImmunology