Author

A. Hanke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. Lindahl· 2 shared A. Martel· 1 shared A. R. Beccari· 1 shared A. V. Vetcher· 1 shared A. Zaliani· 1 shared B. P. Joseph· 1 shared C. Bergh· 1 shared C. Manelfi· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

E. Lindahl

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3 papers

Recent·Most cited

Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel

M. Lycksell, U. Rovsnik, A. Hanke, A. Martel, R. J. Howard, E. Lindahl

This study characterizes the structural dynamics of the calcium-sensitive channel DeCLIC using cryo-EM, SANS, and MD simulations, revealing conformational flexibility in the NTD and calcium binding site.

bioRxiv · May 6, 2022Biophysics

A blueprint for high affinity SARS-CoV-2 Mpro inhibitors from activity-based compound library screening guided by analysis of protein dynamics

J. Gossen, S. Albani, A. Hanke, B. P. Joseph, C. Bergh, M. Kuzikov, E. Costanza, C. Manelfi, P. Storici, P. Gribbon, A. R. Beccari, C. Talarico, F. Spyrakis, E. Lindahl, A. Zaliani, , G. Rossetti

The paper identifies a blueprint for high affinity SARS-CoV-2 Mpro inhibitors by analyzing protein dynamics and redefining druggability through virtual screening and pharmacophore modeling.

bioRxiv · Dec 14, 2020Biophysics

Loop-closure Kinetics Reveal a Stable, Right-handed DNA Intermediate in Cre Recombination

M. J. Shoura, S. M. Giovan, A. V. Vetcher, R. Ziraldo, A. Hanke, S. D. Levene

The paper uses loop-closure kinetics to show a stable, right-handed DNA intermediate in Cre recombination, contrasting with crystallographic data.

bioRxiv · Jul 8, 2019Biophysics