Author

U. Rovsnik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:cryo-EM· 5 Research Focus:protein structure prediction· 4 Organism:bacteria (other)· 3 Approach:deep learning· 3 Approach:experimental assay· 3 Approach:simulation· 3 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2

Frequent Co-Authors

E. Lindahl· 6 shared R. J. Howard· 6 shared M. Lycksell· 3 shared A. Martel· 2 shared B. O. Forsberg· 2 shared C. Bergh· 2 shared C. Blau· 2 shared L. Yvonnesdotter· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersBiophysics

E. Lindahl

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Automated simulation-based membrane-protein refinement into cryo-EM data

L. Yvonnesdotter, U. Rovsnik, C. Blau, M. Lycksell, R. J. Howard, E. Lindahl

This paper introduces an automated method using density-guided molecular dynamics simulations to refine membrane-protein models into cryo-EM maps, showing improved model quality and pixel-size correction.

Biophysical Journal · Jul 1, 2023Peer-reviewedBiophysics

Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM

C. Bergh, U. Rovsnik, R. J. Howard, E. Lindahl

The paper identifies lipid binding sites in the GLIC ion channel using cryo-EM and simulations, revealing state-dependent interactions in both closed and open conformations.

bioRxiv · Jan 6, 2023Biophysics

Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel

M. Lycksell, U. Rovsnik, A. Hanke, A. Martel, R. J. Howard, E. Lindahl

This study characterizes the structural dynamics of the calcium-sensitive channel DeCLIC using cryo-EM, SANS, and MD simulations, revealing conformational flexibility in the NTD and calcium binding site.

bioRxiv · May 6, 2022Biophysics

Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering

M. Lycksell, U. Rovsnik, C. Bergh, N. T. Johansen, A. Martel, L. Porcar, L. Arleth, R. J. Howard, E. Lindahl

This study uses small-angle neutron scattering to examine conformational changes in the bacterial ion channel GLIC under resting and activating conditions, finding no evidence for divergent mechanisms.

bioRxiv · Apr 10, 2021Biophysics

Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations

U. Rovsnik, Y. Zhuang, B. O. Forsberg, M. Carroni, L. Yvonnesdotter, R. J. Howard, E. Lindahl

The paper reports cryo-EM structures and simulations of GLIC under different pH conditions, revealing conformational changes and electrostatic remodeling during proton-induced gating.

bioRxiv · Jan 4, 2021Biochemistry

Characterization of the dynamic resting state of a pentameric ligand-gated ion channel by cryo-electron microscopy and simulations

U. Rovsnik, Y. Zhuang, L. Axelsson, B. O. Forsberg, V. T. Lim, M. Carroni, C. Blau, R. J. Howard, E. Lindahl

The paper uses cryo-EM and simulations to characterize the resting and activating states of GLIC, revealing structural changes and energy landscape dynamics.

bioRxiv · Jun 19, 2020 · PreprintBiophysics