Author

A. R. Beccari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1

Frequent Co-Authors

C. Talarico· 4 shared D. Iaconis· 3 shared M. Allegretti· 3 shared C. Manelfi· 2 shared M. Michaelides· 2 shared R. Bertini· 2 shared A. Caruso· 1 shared A. Cimini· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersCell Biology

C. Talarico

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Relevance of the viral Spike protein/cellular Estrogen Receptor-α interaction for endothelial-based coagulopathy induced by SARS-CoV-2

S. S. Barbieri, F. Cattani, L. Sandrini, M. M. Grillo, C. Talarico, D. Iaconis, L. Lione, E. Salvatori, P. Amadio, G. Garoffolo, M. Maffei, F. Galli, A. R. Beccari, E. Marra, M. Zoppi, , M. Pesce

This study investigates how the SARS-CoV-2 Spike protein interacts with the estrogen receptor-α to enhance pro-coagulant activity in endothelial cells, leading to thrombosis risk.

bioRxiv · Oct 4, 2022 · PreprintCell Biology

The SARS-CoV-2 spike protein binds and modulates estrogen receptors

O. Solis, A. R. Beccari, D. Iaconis, C. Talarico, C. A. Ruiz-Bedoya, J. C. Nwachukwu, A. Cimini, V. Castelli, R. Bertini, M. Montopoli, V. Cocetta, S. Borocci, I. G. Prandi, K. Flavahan, M. Bahr, , M. Michaelides

This study identifies a novel interaction between SARS-CoV-2 spike protein and estrogen receptor alpha, showing its role in modulating ER activity and ACE2 expression in infected cells and tissues.

bioRxiv · May 21, 2022Immunology

Characterization of raloxifene as potential pharmacological agent against SARS-CoV-2 and its variants

D. Iaconis, C. Talarico, C. Manelfi, M. C. Cesta, M. Zippoli, F. Caccuri, G. Matusali, L. Bordi, L. Scorzolini, E. M. Bucci, A. Caruso, E. Nicastri, M. Allegretti, A. R. Beccari

This paper identifies raloxifene as a potential drug candidate for treating COVID-19 through virtual screening and pharmacological characterization across multiple viral variants.

bioRxiv · Oct 22, 2021Pharmacology & Toxicology

A blueprint for high affinity SARS-CoV-2 Mpro inhibitors from activity-based compound library screening guided by analysis of protein dynamics

J. Gossen, S. Albani, A. Hanke, B. P. Joseph, C. Bergh, M. Kuzikov, E. Costanza, C. Manelfi, P. Storici, P. Gribbon, A. R. Beccari, C. Talarico, F. Spyrakis, E. Lindahl, A. Zaliani, , G. Rossetti

The paper identifies a blueprint for high affinity SARS-CoV-2 Mpro inhibitors by analyzing protein dynamics and redefining druggability through virtual screening and pharmacophore modeling.

bioRxiv · Dec 14, 2020Biophysics

PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 controls the transport of E-cadherin

G. Grimaldi, L. Schembri, M. Lo Monte, D. Spano, R. Di Martino, A. R. Beccari, C. Valente, D. Corda

The paper identifies PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 as essential for E-cadherin transport from the trans-Golgi to the plasma membrane.

bioRxiv · May 5, 2020 · PreprintCell Biology