CD8+ T-cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by clonal replacement
H. Aoki, M. Kitabatake, H. Abe, P. Xu, M. Tsunoda, S. Shichino, A. Hara, N. Ouji-Sageshima, C. Motozono, T. Ito, K. Matsushima, S. Ueha
The paper tracks CD8+ T-cell clonotypes after three SARS-CoV-2 mRNA vaccinations and finds that clonotypes from earlier shots are replaced by new ones after subsequent boosters.
bioRxiv · Aug 27, 2022 · PreprintImmunology