Author

S. Ueha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 2 Assay:CITE-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. Shichino· 5 shared K. Matsushima· 4 shared H. Aoki· 3 shared M. Tsunoda· 3 shared H. Abe· 2 shared H. Ogiwara· 2 shared H. Shimizu· 2 shared K. Kondo· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersImmunology

S. Shichino

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Delayed SARS-CoV-2 Spread and Olfactory Cell Lineage Impairment in Close-Contact Infection Syrian Hamster Models

R. Ueha, T. Ito, S. Ueha, R. Furukawa, M. Kitabatake, N. Ouji-Sageshima, T. Uranaka, H. Tanaka, H. Nishijima, K. Kondo, T. Yamasoba

This study investigates SARS-CoV-2 transmission via close contact in Syrian hamsters and shows delayed olfactory cell lineage damage compared to direct infection.

bioRxiv · Sep 3, 2022 · PreprintMicrobiology

CD8+ T-cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by clonal replacement

H. Aoki, M. Kitabatake, H. Abe, P. Xu, M. Tsunoda, S. Shichino, A. Hara, N. Ouji-Sageshima, C. Motozono, T. Ito, K. Matsushima, S. Ueha

The paper tracks CD8+ T-cell clonotypes after three SARS-CoV-2 mRNA vaccinations and finds that clonotypes from earlier shots are replaced by new ones after subsequent boosters.

bioRxiv · Aug 27, 2022 · PreprintImmunology

Clonal spreading of tumor-infiltrating T cells underlies the robust antitumor immune responses

H. Aoki, M. Tsunoda, H. Ogiwara, H. Shimizu, H. Abe, T. Abe, S. Shichino, K. Matsushima, S. Ueha

This study shows that polyclonal expansion of tumor-reactive T cells, not oligoclonal expansion, correlates with antitumor effects in response to anti-PD-L1 and anti-CD4 treatments.

bioRxiv · Apr 19, 2022Immunology

T cell receptor (TCR) repertoire analysis reveals a highly conserved TCR repertoire in a bilateral tumor mouse model

M. Tsunoda, H. Aoki, H. Shimizu, S. Shichino, K. Matsushima, S. Ueha

This study shows that the TCR repertoire is highly conserved between bilateral tumors in a mouse model, supporting its use for temporal analysis of antitumor T cell responses.

bioRxiv · May 13, 2021 · PreprintImmunology

Combining an alarmin HMGN1 peptide with PD-L1 blockade facilitates stem-like CD8+ T cell expansion and results in robust antitumor effects

C.-Y. Chen, S. Ueha, Y. Ishiwata, S. Shichino, S. Yokochi, D. Yang, J. J. Oppenheim, H. Ogiwara, S. Deshimaru, Y. Kanno, T. Ogawa, S. Shibayama, K. Matsushima

This study combines an HMGN1 peptide with PD-L1 blockade to expand stem-like CD8+ T cells and enhance antitumor effects in mouse models.

bioRxiv · Dec 15, 2020Immunology

Understanding olfactory dysfunction in COVID-19: Expression of ACE2, TMPRSS2 and Furin in the nose and olfactory bulb in human and mice

R. Ueha, K. Kondo, R. Kagoya, S. Shichino, S. Ueha, T. Yamasoba

The paper examines ACE2, TMPRSS2, and Furin expression in nasal and olfactory tissues of humans and mice to understand the mechanisms of COVID-19 related anosmia.

bioRxiv · May 15, 2020Pathology