Structure and misfolding of the flexible tripartite coiled coil domain of glaucoma-associated myocilin
S. E. Hill, E. Nguyen, R. K. Donegan, A. Hazel, J. C. Gumbart, R. L. Lieberman
This study determines the structure of myocilin's coiled coil domain, revealing a tripartite Y-shaped architecture and how disease variants alter its quaternary structure without affecting stability.
Structure · Nov 1, 2017Peer-reviewedBiochemistry