E. Nguyen

Single cell spatial transcriptomic profiling of childhood-onset lupus nephritis reveals complex interactions between kidney stroma and infiltrating immune cells.

This study uses single cell spatial transcriptomics to analyze kidney tissue from childhood-onset lupus nephritis patients, revealing spatial interactions between immune cells and kidney stroma.

Sugar transporter Slc37a2 regulates bone metabolism via a dynamic tubular lysosomal network in osteoclasts

This study identifies Slc37a2 as a sugar transporter in osteoclast secretory lysosomes, showing its role in bone metabolism through dynamic tubular networks and its impact on bone mass.

CODEC enables 'single duplex' sequencing

CODEC improves mutation detection by combining NGS throughput with single-molecule resolution, achieving similar accuracy with fewer reads.

Quantitative profiling of protease specificity.

The paper develops a method to quantitatively profile protease specificity using selectome analysis, substrate phage display, and next-generation sequencing to distinguish between closely related proteases.

Evolution of an enzyme conformational ensemble guides design of an efficient biocatalyst

The paper uses X-ray crystallography to study conformational changes in an evolved enzyme, leading to the design of a more efficient biocatalyst by focusing on active-site mutations.

Local Contractions Regulate E-Cadherin Adhesions, Rigidity Sensing and Epithelial Cell Sorting

The paper shows that local contractions regulate E-cadherin adhesions, rigidity sensing, and epithelial cell sorting through mechanical testing of neighboring cells.

Structure and misfolding of the flexible tripartite coiled coil domain of glaucoma-associated myocilin

This study determines the structure of myocilin's coiled coil domain, revealing a tripartite Y-shaped architecture and how disease variants alter its quaternary structure without affecting stability.