Author

R. K. Donegan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. R. Reddi· 2 shared A. Hazel· 1 shared A. Mitra· 1 shared D. Kornitzer· 1 shared E. Nguyen· 1 shared G. Brown· 1 shared H. A. Dailey· 1 shared H. Yang· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

A. R. Reddi

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The terminal heme synthetic enzyme, Coproheme Decarboxylase, coordinates heme synthesis and uptake in response to iron in Mycobacteria

R. K. Donegan, J. Copeland, S. Edgha, G. Brown, O. F. Hale, A. Mitra, H. Yang, H. A. Dailey, M. Niederweis, P. Jain, A. R. Reddi

This study identifies Coproheme Decarboxylase (ChdC) as a regulator of heme synthesis and uptake in Mycobacterium tuberculosis, showing it controls heme bioavailability and iron acquisition in response to iron availability.

bioRxiv · May 10, 2021 · PreprintMicrobiology

Using genetically encoded heme sensors to probe the mechanisms of heme uptake and homeostasis in Candida albicans

Z. Weissman, M. Pinsky, R. K. Donegan, A. R. Reddi, D. Kornitzer

This study uses genetically encoded heme sensors to show that C. albicans takes up heme from hemoglobin and hemin via different pathways and uses Hmx1 to prevent heme toxicity.

bioRxiv · Jul 26, 2020Microbiology

Structure and misfolding of the flexible tripartite coiled coil domain of glaucoma-associated myocilin

S. E. Hill, E. Nguyen, R. K. Donegan, A. Hazel, J. C. Gumbart, R. L. Lieberman

This study determines the structure of myocilin's coiled coil domain, revealing a tripartite Y-shaped architecture and how disease variants alter its quaternary structure without affecting stability.

Structure · Nov 1, 2017Peer-reviewedBiochemistry