Age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death
T. Baldensperger, T. Jung, T. Heinze, T. Schwerdtle, A. Hoehn, T. Grune
This study isolates authentic lipofuscin from cardiac tissue and shows it induces oxidative stress, lysosomal dysfunction, and pyroptotic cell death in fibroblasts.
bioRxiv · Mar 25, 2024Cell Biology