Proofreading and single-molecule sensitivity in T-cellreceptor signaling by condensate nucleation
W. L. White, D. Baker, J. T. Groves, D. Baker, A. J. Ben-sasson, H. Y. Kueh
This paper shows that T-cell receptor signaling uses condensate nucleation to selectively detect single foreign peptides by amplifying weak signals and setting spatial-temporal thresholds.
bioRxiv · Mar 13, 2024Biophysics