Lung injury epigenetically primes mesenchyme for amplified activation upon re-injury
D. L. Jones, N. Caporarello, J. A. Meridew, K. M. Choi, A. J. Haak, P. A. Link, Q. Tan, T. Ordog, G. Ligresti, D. J. Tschumperlin
This study shows that lung mesenchyme retains epigenetic memory of prior injury, leading to amplified fibrogenic responses upon re-injury, with Runx1 playing a key role.
bioRxiv · Mar 4, 2022Cell Biology