Author

T. Ordog

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

D. J. Tschumperlin· 2 shared D. L. Jones· 2 shared G. Ligresti· 2 shared J. A. Meridew· 2 shared J.-H. Lee· 2 shared K. M. Choi· 2 shared N. Caporarello· 2 shared P. A. Link· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

D. J. Tschumperlin

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4 papers

Recent·Most cited

Lung injury epigenetically primes mesenchyme for amplified activation upon re-injury

D. L. Jones, N. Caporarello, J. A. Meridew, K. M. Choi, A. J. Haak, P. A. Link, Q. Tan, T. Ordog, G. Ligresti, D. J. Tschumperlin

This study shows that lung mesenchyme retains epigenetic memory of prior injury, leading to amplified fibrogenic responses upon re-injury, with Runx1 playing a key role.

bioRxiv · Mar 4, 2022Cell Biology

Protein hyperacylation links mitochondrial dysfunction with nuclear organization

J. A. Smestad, M. McCauley, M. Amato, Y. Xiong, J. Liu, Y.-C. Sin, J. Ellingson, Y. Chen, F. Al Khazal, B. Wilbanks, J.-H. Lee, T. Ordog, I. Rouzina, M. C. Williams, J. Locasale, L. J. Maher

This study investigates how metabolic dysfunction, specifically through hyperacylation of histones and cohesin, affects chromatin structure across multiple scales, revealing metabolic regulation of chromatin organization.

bioRxiv · Oct 23, 2020 · PreprintCell Biology

ZNF416 is a pivotal transcriptional regulator of fibroblast mechano-activation

D. L. Jones, J. A. Meridew, M. T. Ducharme, K. L. Lydon, K. M. Choi, N. Caporarello, Q. Tan, P. A. Link, A. M. Diaz Espinosa, Y. Xiong, J.-H. Lee, Z. Ye, H. Yan, T. Ordog, G. Ligresti, , D. J. Tschumperlin

This study identifies ZNF416 as a key transcriptional regulator that mediates fibroblast responses to matrix stiffness through chromatin accessibility and gene expression changes.

bioRxiv · Jul 23, 2020Cell Biology

Pro-inflammatory cytokines disrupt β-cell circadian clocks in diabetes

N. Javeed, M. R. Brown, K. Rakshit, T. Her, Z. Ye, J. H. Lee, T. Ordog, A. V. Matveyenko

This study shows that IL-1β disrupts β-cell circadian clocks by impairing Bmal1 expression and alters its DNA-binding patterns, linking circadian disruption to β-cell failure in diabetes.

bioRxiv · Aug 15, 2019 · PreprintCell Biology