Author

A. J. Middleton

Primary ORCID profile (0000-0002-6075-4061 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

A. J. MiddletoniD1 paper · University of Otago

Biology Disciplines

Click to filter author papers

Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. L. Day· 2 shared J. Teyra· 2 shared J. Zhu· 2 shared S. S. Sidhu· 2 shared J. M. McAlpine· 1 shared M. J. Currie· 1 shared N. Pudjihartono· 1 shared R. C. Dobson· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

C. L. Day

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Structural and biophysical characterisation of ubiquitin variants that specifically inhibit the ubiquitin conjugating enzyme Ube2d2

J. M. McAlpine, J. Zhu, N. Pudjihartono, J. Teyra, M. J. Currie, R. C. Dobson, S. S. Sidhu, C. L. Day, A. J. Middleton

The paper identifies ubiquitin variants that inhibit Ube2d2, showing structural and biophysical properties that suggest potential for developing selective E2 enzyme inhibitors.

bioRxiv · Mar 10, 2024Biochemistry

Identification of ubiquitin variants that inhibit the E2 ubiquitin conjugating enzyme, Ube2k

A. J. Middleton, J. Teyra, J. Zhu, S. S. Sidhu, C. L. Day

The paper identifies ubiquitin variants that inhibit Ube2k by binding to a hydrophobic cleft, blocking ubiquitin transfer and enzyme activation.

bioRxiv · May 28, 2021Biochemistry