MLF2 modulates phase separated nuclear envelope condensates that provoke dual proteotoxicity
S. M. Prophet, A. J. Rampello, R. F. Niescier, J. E. Shaw, A. J. Koleske, C. Schlieker
The paper identifies MLF2 as a catalyst of phase separation in nuclear envelope blebs that causes dual proteotoxicity by stabilizing ubiquitinated proteins and sequestering chaperones in DYT1 dystonia.
bioRxiv · Oct 26, 2021 · PreprintCell Biology