L. Shao

A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope

This study quantifies the timeline of nuclear autophagy in yeast, revealing a role for Dnm1 in nuclear envelope remodeling during cargo removal.

Spatial segregation and aging of metabolic processes underlie phenotypic heterogeneity in mycobacteria

The paper identifies spatial segregation and aging-related changes in metabolic processes in mycobacteria, contributing to phenotypic heterogeneity.

Three-dimensional structured illumination microscopy with enhanced axial resolution

The paper introduces two methods to enhance axial resolution in 3D SIM microscopy, achieving isotropic resolution with minimal hardware changes and using deep learning for improved imaging.

Membrane remodeling properties of the Parkinson's disease protein LRRK2

This study shows that LRRK2 binds and remodels lipid membranes, suggesting its role in membrane dynamics and signaling.

Microbial signals and lymphotoxin drive TNF-independent death of A20 and ABIN-1 deficient epithelium

The paper shows that microbial signals, MyD88, and lymphotoxin contribute to TNF-independent intestinal injury after A20 and Abin-1 deletion in intestinal epithelial cells.

G2 stem cells orchestrate time-directed, long-range coordination of calcium signaling during skin epidermal regeneration

The paper uses a new machine learning tool to analyze calcium signaling dynamics in epidermal stem cells during regeneration, revealing that G2 stem cells coordinate long-range signaling through gap junctions.

CPEB2 m6A Methylation Regulates BTB Permeability via Affecting Splicing Factor SRSF5 Stability

This study identifies a regulatory pathway involving CPEB2 m6A methylation that affects BTB permeability through SRSF5 and P51-ETS1, enhancing drug efficacy in glioma treatment.

Clinically applicable histopathological diagnosis system for gastric cancer detection using deep learning

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

CTLA-4 blockade reverses the Foxp3+ T-regulatory-cell suppression of anti-tuberculosis T-cell effector responses

This study shows that blocking CTLA-4 reverses Treg cell suppression of anti-TB T-cell responses in tuberculosis patients.

Torsin ATPases are required to complete nuclear pore complex biogenesis in interphase

The paper identifies MLF2 as a component of nuclear envelope blebs and shows that Torsin ATPases are essential for completing nuclear pore complex biogenesis in interphase.

Integrated multi-omics analysis to study the effects of simulated weightlessness on rhesus macaques (Macaca mulatta)

This study uses multi-omics analysis to examine the effects of simulated weightlessness on rhesus macaques, identifying molecular changes in blood, muscle, brain regions, and fecal samples.

Tandem duplications lead to novel expression patterns through exon shuffling in D. yakuba

This paper examines tandem duplications in D. yakuba, finding that they lead to novel expression patterns through exon shuffling and chimeric structures, rather than simple gene dosage changes.