Drug targeting to sites of oxidative stress using the Baeyer-Villiger reaction
T. D. Avery, J. Li, D. J. L. Turner, F. R. Cherry, M. S. Ur Rasheed, C. Aguilar, A. J. Shepherd, J. Yu, P. M. Grace, A. D. Abell
The paper develops a 1,2-dicarbonyl compound that selectively activates Nrf2 at sites of oxidative stress, reversing pain in mice and offering a targeted approach for treating oxidative stress-related disorders.
bioRxiv · Sep 3, 2021 · PreprintPharmacology & Toxicology