Author

A. J. Timmis

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Biochemistry· 1

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. A. Johnson· 1 shared D. S. Gkotsi· 1 shared F. Cross· 1 shared H. Ollerton· 1 shared N. A. Riobo-Del Galdo· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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1 shared paperBiochemistry

C. A. Johnson

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1 paper

Recent·Most cited

The Hedgehog receptors PTCH1 and PTCH2 exist as active homomeric and heteromeric complexes

A. J. Timmis, F. Cross, D. S. Gkotsi, H. Ollerton, C. A. Johnson, N. A. Riobo-Del Galdo

This study shows PTCH1 and PTCH2 form active homomeric and heteromeric complexes, with PTCH2 having minimal cholesterol transport but essential cation transport residues, and heteromers can compensate for mutations.

bioRxiv · Aug 8, 2023 · PreprintBiochemistry