Sulfation of glycosaminoglycans depends on catalytic activity of a lithium-inhibited phosphatase
B. S. Eisele, Z. A. Luka, A. J. Wu, F. Yang, A. T. Hale, J. D. York
This study shows that BPNT2 catalytic activity is essential for GAG sulfation, and lithium inhibits this process, affecting extracellular matrix composition and lithium's therapeutic effects.
bioRxiv · Jun 24, 2021Biochemistry