Two type II phosphatidylinositol 4-kinases function sequentially in tubule-mediated cargo delivery from early endosomes to melanosomes
Y. Zhu, S. Li, A. Jaume, R. A. Jani, C. Delevoye, G. Raposo, M. S. Marks
The paper shows that PI4KII and PI4KIIβ sequentially generate PtdIns4P to support BLOC-1-dependent tubule elongation for melanosome content delivery.
bioRxiv · Oct 19, 2021Cell Biology