Hypoxia-induced extracellular matrix changes are conserved in cancer and directly impact radiotherapy benefit
Conrado Guerrero Quiles, A. Julia Gonzalez, Arnaud Foussat, Argyro Olympitis, Taha Lodhi, Vicky Smith, Mark Reardon, Rekaya Shabbir, Sapna Lunj, Kimberley Jayne Reeves, Alexander R. Baker, Michael Eyers, Gayle B. Marshall, Timothy Smith, Peter Hoskin, , Catharine West
The paper identifies hypoxia-induced ECM changes across cancers and shows they predict radiotherapy benefit.
bioRxiv · Apr 4, 2025 · PreprintCancer Biology