Ananya Choudhury

Spatially-resolved multimodal profiling identifies functionally-heterogeneous cancer-associated fibroblasts associated with poor radiotherapy outcomes in muscle-invasive bladder cancer.

This study identifies functionally heterogeneous cancer-associated fibroblasts in muscle-invasive bladder cancer linked to poor radiotherapy outcomes.

Whole-genome pre-amplification as a viable approach for genomic screening of FFPE-derived DNA samples

This study evaluates DLMDA for improving DNA yield from FFPE samples but finds it reduces CNA sensitivity.

WSB-1 regulates DNA repair and the response to DNA damage response inhibitors in breast cancer

This study shows WSB-1 regulates DNA repair and enhances sensitivity to DNA damage response inhibitors in breast cancer.

Fractionated radiation alters the extracellular matrix produced by muscle-invasive bladder cancer cells

This study shows fractionated radiation changes the extracellular matrix (ECM) composition in muscle-invasive bladder cancer, with ECM-related genes linked to poor prognosis.

Hypoxia-induced extracellular matrix changes are conserved in cancer and directly impact radiotherapy benefit

The paper identifies hypoxia-induced ECM changes across cancers and shows they predict radiotherapy benefit.

Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-β1 signaling mechanism

This study identifies MMP11 as a blood-based biomarker for prostate cancer progression, regulated by the ALDH1A1-TGF-β1 signaling pathway.

Investigating the impact of the interstitial fluid flow and hypoxia interface on cancer biology using a spheroid-on-chip perfusion system

This study uses a spheroid-on-chip system to analyze how interstitial fluid flow and hypoxia affect cancer gene expression and identifies potential biomarkers.