Myopathy mutations in DNAJB6 slow conformer specific substrate processing that is rescued by NEF modulation
A. K. Bhadra, M. J. Rau, J. A. Daw, J. A. J. Fitzpatrick, C. C. Weihl, H. True
This study identifies how LGMDD1 mutations in DNAJB6 disrupt chaperone function and shows that modulating NEF can rescue substrate processing defects.
bioRxiv · Dec 22, 2021 · PreprintBiochemistry