Author

M. J. Rau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Organism:plant (other)· 1

Frequent Co-Authors

J. A. J. Fitzpatrick· 2 shared A. K. Bhadra· 1 shared C. C. Weihl· 1 shared G. Brannigan· 1 shared H. Hu· 1 shared H. True· 1 shared H. Zhao· 1 shared J. A. Daw· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

J. A. J. Fitzpatrick

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3 papers

Recent·Most cited

Lipid nanodisc scaffold and size alters the structure of a pentameric ligand-gated ion channel

V. Dalal, M. J. Arcario, J. T. Petroff, N. M. Dietzen, M. J. Rau, J. A. J. Fitzpatrick, G. Brannigan, W. W. L. Cheng

This study shows that different lipid nanodisc scaffolds and sizes alter the structure of the pentameric ligand-gated ion channel ELIC, with larger nanodiscs promoting more activated conformations.

bioRxiv · Nov 20, 2022Biophysics

Myopathy mutations in DNAJB6 slow conformer specific substrate processing that is rescued by NEF modulation

A. K. Bhadra, M. J. Rau, J. A. Daw, J. A. J. Fitzpatrick, C. C. Weihl, H. True

This study identifies how LGMDD1 mutations in DNAJB6 disrupt chaperone function and shows that modulating NEF can rescue substrate processing defects.

bioRxiv · Dec 22, 2021 · PreprintBiochemistry

Cryo-EM structure of a proton-activated chloride channel TMEM206

Z. Deng, Y. Zhao, J. Feng, J. Zhang, H. Zhao, M. J. Rau, J. Fitzpatrick, H. Hu, P. Yuan

The paper reports the cryo-EM structure of pufferfish TMEM206, revealing its trimeric architecture and chloride ion selectivity, and compares it to sodium channels despite sequence differences.

bioRxiv · Nov 5, 2020Biophysics