Sera from individuals with narrowly focused influenza virus antibodies rapidly select viral escape mutations in ovo
A. K. F. Davis, K. McCormick, M. E. Gumina, J. Petrie, E. T. Martin, K. S. Xue, J. D. Bloom, A. Monto, F. Bushman, S. E. Hensley
The paper shows that sera from humans with narrowly focused influenza virus antibodies select for single HA escape mutations in ovo, reducing antibody binding.
bioRxiv · May 17, 2018Microbiology