S. E. Hensley

Influenza virus antibodies inhibit antigen-specific de novo B cell responses in mice

This study shows that pre-existing antibodies inhibit de novo B cell responses to influenza antigens in mice, but not to other vaccine antigens.

Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus

This study develops an mRNA vaccine against clade 2.3.4.4b H5 avian influenza virus and shows it is immunogenic and protective in mice and ferrets.

Evaluation of mRNA-LNP and adjuvanted protein SARS-CoV-2 vaccines in a maternal antibody mouse model

This study evaluates how maternal antibodies affect immune responses to different SARS-CoV-2 vaccines in mice, finding that mRNA-LNP and adjuvanted protein vaccines can overcome maternal antibody inhibition.

Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies

The paper examines immune responses in vaccinated individuals during SARS-CoV-2 breakthrough infection, showing early activation of memory T cells and subsequent neutralizing antibody production.

IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding

This study shows that IgG3 subclass antibodies neutralize antigenically drifted influenza and SARS-CoV-2 variants more effectively than other subclasses.

Nucleoside-modified mRNA-based influenza vaccines circumvent problems associated with H3N2 vaccine strain egg-adaptation

This study compares H3N2 vaccine efficacy between mRNA-LNP and egg-based vaccines, finding that mRNA-LNP vaccines elicit better neutralizing antibodies and protection against wild-type H3N2 virus.

Disease diagnostics using machine learning of immune receptors

The paper develops Mal-ID, a machine learning framework using immune receptor data to diagnose diseases, detecting infections, autoimmune disorders, and vaccine responses.

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

This study examines antibody and memory B cell responses after a third dose of SARS-CoV-2 mRNA vaccine, showing improved antibody quality and stable memory B cells capable of recognizing multiple variants.

The 2009 pandemic H1N1 hemagglutinin stalk remained antigenically stable after circulating in humans for a decade

The paper investigates whether the HA stalk of the 2009 pandemic H1N1 virus has undergone antigenic drift over a decade and finds it remains antigenically stable.

Rapid induction of antigen-specific CD4+ T cells guides coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination

This study shows that mRNA vaccination rapidly induces antigen-specific CD4+ T cells, which coordinate humoral and cellular immune responses, with booster doses enhancing T cell responses in naive individuals.

An egg-derived sulfated N-Acetyllactosamine glycan is an antigenic decoy of influenza virus vaccines

This study identifies an egg-derived sulfated N-Acetyllactosamine glycan in influenza vaccines that acts as an antigenic decoy, inducing antibodies that may reduce immune response to protective epitopes.

Pre-existing immunity provides a barrier to airborne transmission of influenza viruses

The paper shows that pre-existing non-neutralizing immunity in ferrets blocks airborne transmission of seasonal influenza viruses.

Vaccination reshapes the virus-specific T cell repertoire in unexposed adults

This study examines how pre-existing T cell characteristics influence the immune response to a yellow fever vaccine, finding that memory T cells and rare populations shape post-vaccination responses.

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

The paper identifies distinct immunotypes in COVID-19 patients through high-dimensional cytometry, linking them to disease severity and potential therapeutic implications.

Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection

The paper identifies broad immune perturbations in severe COVID-19, including innate and adaptive immune cell changes and heterogeneity in B cell responses and antibody production.

Identification of antibodies targeting the H3N2 hemagglutinin receptor binding site following vaccination of humans

This study identifies H3N2 HA RBS-targeting antibodies in humans, showing some can be broadly reactive despite sensitivity to substitutions near the RBS.

Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

The paper maps how amino-acid mutations in influenza's hemagglutinin affect neutralization by polyclonal human sera, showing individual variation in escape mutations not observed in ferrets.

Assessing the protective potential of H1N1 influenza virus hemagglutinin head and stalk antibodies in humans

This study assesses the protective role of H1N1 influenza virus hemagglutinin head and stalk antibodies in humans, finding both are associated with protection against infection.

Sera from individuals with narrowly focused influenza virus antibodies rapidly select viral escape mutations in ovo

The paper shows that sera from humans with narrowly focused influenza virus antibodies select for single HA escape mutations in ovo, reducing antibody binding.

Identification of human vaccinees that possess antibodies targeting the egg-adapted hemagglutinin receptor binding site of an H1N1 influenza vaccine strain

The paper identifies a subset of vaccinated individuals with higher antibody titers against an egg-adapted H1N1 influenza strain's receptor binding site.

Complete mapping of viral escape from neutralizing antibodies

This study maps viral escape mutations from neutralizing antibodies by creating all replication-competent variants and using deep sequencing to identify enriched mutations.