Global Dynamics as Communication Sensors in Peptide Synthetase Cyclization Domains.
S. H. Mishra, A. K. Kancherla, K. A. Marincin, G. Bouvignies, S. Nerli, N. Sgourakis, D. P. Dowling, D. P. Frueh
The paper uses NMR to show that global dynamics in NRPS cyclization domains act as sensors for substrate interactions, enabling allosteric responses across the enzyme.
bioRxiv · Oct 6, 2021 · PreprintBiophysics