Author

N. Sgourakis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Dubey· 1 shared A. K. Kancherla· 1 shared D. P. Dowling· 1 shared D. P. Frueh· 1 shared G. Bouvignies· 1 shared H. Arthanari· 1 shared K. A. Marincin· 1 shared S. H. Mishra· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. Dubey

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2 papers

Recent·Most cited

Global Dynamics as Communication Sensors in Peptide Synthetase Cyclization Domains.

S. H. Mishra, A. K. Kancherla, K. A. Marincin, G. Bouvignies, S. Nerli, N. Sgourakis, D. P. Dowling, D. P. Frueh

The paper uses NMR to show that global dynamics in NRPS cyclization domains act as sensors for substrate interactions, enabling allosteric responses across the enzyme.

bioRxiv · Oct 6, 2021 · PreprintBiophysics

A slow-exchange conformational switch regulates off-target cleavage by high-fidelity Cas9

V. S. De Paula, A. Dubey, H. Arthanari, N. Sgourakis

This study identifies a conformational switch in Cas9 that reduces off-target cleavage by enabling REC3 domain scanning for proper base pairing.

bioRxiv · Dec 6, 2020 · PreprintBiochemistry