Collateral sensitivity as a strategy to suppress resistance emergence: the challenge of diverse evolutionary pathways
R. E. K. Mandt, M. R. Luth, M. A. Tye, R. Mazitschek, S. Ottilie, E. A. Winzeler, M. J. Lafuente-Monasterio, F. J. Gamo, D. F. Wirth, A. K. Lukens
This study investigates collateral sensitivity between DHODH inhibitors to suppress malaria resistance, finding that cross-resistant mutants can emerge despite initial sensitivity.
bioRxiv · Apr 7, 2022Microbiology