The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent.
S. Skopelja-Gardner, J. An, J. Tai, L. Tanaka, X. Sun, P. Hermanson, M. Kawasumi, R. Green, M. Gale, A. Kalus, V. P. Werth, K. B. Elkon
This study shows UVB exposure triggers local and systemic Type I interferon responses in mice, which are largely cGAS-dependent and contribute to disease flares in SLE.
bioRxiv · Jan 30, 2020Immunology