M. Gale

Exposure of negative-sense viral RNA in the cytoplasm initiates innate immunity to West Nile virus

The paper identifies that exposure of single-stranded negative-sense viral RNA outside replication compartments during flavivirus infection triggers innate immunity via RIG-I interaction.

CD4-mediated immunity shapes neutrophil-driven tuberculous pathology

This study shows that prior immunity influences tuberculosis lesion structure by modulating neutrophil and T cell responses, leading to different pathological outcomes.

Pre-challenge gut microbial signature predicts RhCMV/SIV vaccine efficacy in rhesus macaques

The paper identifies a gut microbial signature predictive of RhCMV/SIV vaccine efficacy in rhesus macaques using 16S rRNA analysis and compositional data techniques.

Disruption of myelin structure and oligodendrocyte maturation in a pigtail macaque model of congenital Zika infection

This study investigates the effects of prenatal Zika virus exposure on fetal myelin structure and oligodendrocyte maturation in pigtail macaques, finding disruptions in myelin formation and gene expression related to oligodendrocyte development.

Cellular RNA interacts with MAVS to promote antiviral signaling

The paper shows that cellular RNA interacts with MAVS to scaffold signaling proteins and promote antiviral signaling by facilitating IRF3 phosphorylation.

Elevated peripheral and nervous system inflammation is associated with decreased short-chain fatty acid levels in Zika-virus infected macaques

This study links reduced short-chain fatty acid levels with elevated inflammation in Zika-virus infected macaques, suggesting microbial dysfunction contributes to CNS and systemic inflammation.

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 that Exhibits Antiviral Efficacy in SARS-CoV-2 Infected African Green Monkeys

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

This study shows that modulating type I interferon responses in rhesus macaques reduces SARS-CoV-2 viral load and inflammation, suggesting a potential therapeutic strategy for severe COVID-19.

A small molecule RIG-I agonist serves to adjuvant broad multifaceted influenza virus vaccine immunity

This paper identifies a small molecule RIG-I agonist, KIN1148, that enhances influenza vaccine immunity by activating non-canonical RIG-I pathways to boost both antibody and T cell responses.

High-risk microbial signatures are associated with severe parasitemia in controlled Plasmodium infections of both humans and rhesus macaques

The paper identifies a high-risk microbial signature in the gut microbiome associated with severe parasitemia in both humans and rhesus macaques during controlled Plasmodium infections.

Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease and pathology and reduce viral shedding following challenge with heterologous SARS-CoV2 variants of concern

This study evaluates a replicating RNA vaccine against SARS-CoV-2 variants, showing protection from disease and reduced viral shedding after heterologous challenge.

Single cell based high-throughput Ig and TCR repertoire sequencing analysis in rhesus macaques

This study develops and validates high-throughput single-cell immune repertoire sequencing for rhesus macaques, enabling analysis of Ig and TCR repertoires in over 60,000 cells.

Endomembrane targeting of human OAS1 p46 augments antiviral activity

This study shows that the OAS1 p46 isoform, targeted to the endomembrane system, enhances antiviral activity against RNA viruses and is associated with COVID-19 severity.

SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function

This study shows SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, causing electrical and mechanical dysfunction in cardiac cells.

De novo design of ACE2 protein decoys to neutralize SARS-CoV-2

The paper designs de novo ACE2 protein decoys to neutralize SARS-CoV-2 by blocking viral entry, showing high affinity and potent in vitro inhibition.

Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates

The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent.

This study shows UVB exposure triggers local and systemic Type I interferon responses in mice, which are largely cGAS-dependent and contribute to disease flares in SLE.

Systematic profiling of full-length immunoglobulin and T-cell receptor repertoire diversity in rhesus macaque through long read transcriptome sequencing

This study uses long-read sequencing to profile full-length Ig and TCR repertoires in rhesus macaques, revealing significant diversity missed by traditional methods.

Human DNA-PK activates a STING-independent DNA sensing pathway

The paper identifies a STING-independent DNA sensing pathway in human cells, mediated by DNA-PK, and shows its role in antiviral responses and distinct activation from DNA damage.

Role of RIG-I-like receptors in innate immune sensing of Coxsackievirus B3 and encephalomyocarditis virus in murine macrophages and fibroblasts

The paper investigates how RIG-I and MDA5 sense Coxsackievirus B3 and encephalomyocarditis virus in macrophages and fibroblasts, showing cell-type dependent innate immune responses.