Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation
L. Yshii, E. Pasciuto, P. Bielefeld, L. Mascali, P. Lemaitre, M. Marino, J. Dooley, L. Kouser, S. Verschoren, V. Lagou, H. Kemps, P. Gervois, A. de Boer, O. Burton, J. Wahis, , A. Liston
This study delivers IL2 to astrocytes in the brain to increase resident Tregs and protect against neuroinflammation without affecting the peripheral immune system.
bioRxiv · Feb 28, 2022Immunology