Author

L. Kouser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Liston· 3 shared J. Dooley· 3 shared B. de Strooper· 2 shared E. Pasciuto· 2 shared K. Singh· 2 shared L. Mascali· 2 shared L. Yshii· 2 shared M. Aloulou· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

A. Liston

Mutual co-authors in cluster

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3 papers

Recent·Most cited

The AppNL-G-F mouse model of Alzheimer's disease is refractory to regulatory T cell treatment

L. Yshii, L. Mascali, L. Kouser, P. Lemaitre, M. Marino, J. Dooley, O. Burton, J. Haughton, Z. Callaerts-Vegh, B. de Strooper, M. Holt, E. Pasciuto, A. Liston

This study shows that regulatory T cell therapy does not improve Alzheimer's disease progression in AppNL-G-F mice, suggesting limited therapeutic potential for this model.

bioRxiv · Mar 11, 2022 · PreprintImmunology

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

L. Yshii, E. Pasciuto, P. Bielefeld, L. Mascali, P. Lemaitre, M. Marino, J. Dooley, L. Kouser, S. Verschoren, V. Lagou, H. Kemps, P. Gervois, A. de Boer, O. Burton, J. Wahis, , A. Liston

This study delivers IL2 to astrocytes in the brain to increase resident Tregs and protect against neuroinflammation without affecting the peripheral immune system.

bioRxiv · Feb 28, 2022Immunology

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

C. E. Whyte, K. Singh, O. T. Burton, M. Aloulou, A. Moudra, C. P. Roca, F. J. Naranjo, F. Lombard-Vadnais, L. Kouser, T. Hochepied, T. Y. F. Halim, S. Schlenner, S. Lesage, J. Dooley, A. Liston

This study identifies context-dependent effects of IL-2 on immune circuits by rewiring its production sources in mice, revealing distinct cellular responses and potential adverse effects.

bioRxiv · Dec 18, 2020Immunology