Author

J. Dooley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 7 Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 3 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Liston· 6 shared E. Pasciuto· 3 shared K. Singh· 3 shared L. Kouser· 3 shared O. Burton· 3 shared P. Lemaitre· 3 shared A. Moudra· 2 shared B. de Strooper· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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6 shared papersImmunology

A. Liston

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Disruption of IL-17 signaling in the respiratory mucosa results in invasive streptococcal infection

M. Pandey, J.-L. Mills, A. Lepletier, V. Ozberk, J. Dooley, J. Kaden, A. Calcutt, Y. Huo, A. Hicks, A. Zaid, M. Good

This study shows that IL-17 deficiency in mice leads to increased S. pyogenes dissemination after respiratory infection, contributing to invasive streptococcal disease.

bioRxiv · Nov 10, 2023 · PreprintImmunology

The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program

O. Burton, O. Bricard, S. Tareen, V. Gergelits, S. Andrews, C. P. Roca, C. Whyte, S. Junius, A. Brajic, E. Pasciuto, M. Ali, P. Lemaitre, S. M. Schlenner, H. Ishigame, B. Brown, , A. Liston

The paper analyzes tissue-resident regulatory T cells (Tregs) in non-lymphoid organs, showing they share phenotypes, transient residency, and TCR sequences, with tissue-agnostic re-entry capabilities.

bioRxiv · Aug 14, 2023Immunology

Investigating the effects of radiation, T cell depletion, and bone marrow transplantation on murine gut microbiota

J. Kreisinger, J. Dooley, K. Singh, D. Cizkova, L. Schmiedova, B. Bendova, A. Liston, A. Moudra

This study examines how radiation, T cell depletion, and bone marrow transplantation affect the gut microbiota in mice, revealing region-specific changes and the impact of T cells on microbial composition.

bioRxiv · Jul 10, 2023Immunology

The AppNL-G-F mouse model of Alzheimer's disease is refractory to regulatory T cell treatment

L. Yshii, L. Mascali, L. Kouser, P. Lemaitre, M. Marino, J. Dooley, O. Burton, J. Haughton, Z. Callaerts-Vegh, B. de Strooper, M. Holt, E. Pasciuto, A. Liston

This study shows that regulatory T cell therapy does not improve Alzheimer's disease progression in AppNL-G-F mice, suggesting limited therapeutic potential for this model.

bioRxiv · Mar 11, 2022 · PreprintImmunology

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

L. Yshii, E. Pasciuto, P. Bielefeld, L. Mascali, P. Lemaitre, M. Marino, J. Dooley, L. Kouser, S. Verschoren, V. Lagou, H. Kemps, P. Gervois, A. de Boer, O. Burton, J. Wahis, , A. Liston

This study delivers IL2 to astrocytes in the brain to increase resident Tregs and protect against neuroinflammation without affecting the peripheral immune system.

bioRxiv · Feb 28, 2022Immunology

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

C. E. Whyte, K. Singh, O. T. Burton, M. Aloulou, A. Moudra, C. P. Roca, F. J. Naranjo, F. Lombard-Vadnais, L. Kouser, T. Hochepied, T. Y. F. Halim, S. Schlenner, S. Lesage, J. Dooley, A. Liston

This study identifies context-dependent effects of IL-2 on immune circuits by rewiring its production sources in mice, revealing distinct cellular responses and potential adverse effects.

bioRxiv · Dec 18, 2020Immunology

Intrinsic defects in lymph node stromal cells underpin poor germinal center responses during aging

A. E. Denton, A. Silva-Cayetano, J. Dooley, D. L. Hill, E. J. Carr, P. A. Robert, M. Meyer-Hermann, A. Liston, M. A. Linterman

This study shows that aging impairs lymph node stromal cells' ability to respond to vaccination, limiting germinal center formation and antibody production.

bioRxiv · May 7, 2020 · PreprintImmunology

In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling

Z. Jagani, G. Chenail, K. Xiang, G. Bushold, H.-E. C. Bhang, A. Li, G. Elliott, J. Zhu, A. Vattay, T. Gilbert, A. Bric, R. Kikkawa, V. Dubost, R. Terranova, J. Cantwell, , Haas

This study validates novel BRM/BRG1 ATPase inhibitors as chemical probes for SWI/SNF chromatin remodeling and shows their therapeutic potential in BRG1-mut lung cancers.

bioRxiv · Oct 22, 2019 · PreprintCancer Biology