The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma
Z. Ren, H. Lantermans, A. Kuil, W. Kraan, F. Arenzana-Seisdedos, M. J. Kersten, M. Spaargaren, S. T. Pals
This study identifies CXCL12gamma as a membrane-bound chemokine that promotes multiple myeloma cell adhesion and drug resistance through interactions with heparan sulfate proteoglycans.
bioRxiv · Sep 29, 2020Cancer Biology