Author

M. Spaargaren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. T. Pals· 2 shared A. Kuil· 1 shared A. P. Vlaar· 1 shared B. M. Nijmeijer· 1 shared C. J. van Noesel· 1 shared C. Maas· 1 shared E. E. Eldering· 1 shared F. Arenzana-Seisdedos· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

S. T. Pals

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma

Z. Ren, H. Lantermans, A. Kuil, W. Kraan, F. Arenzana-Seisdedos, M. J. Kersten, M. Spaargaren, S. T. Pals

This study identifies CXCL12gamma as a membrane-bound chemokine that promotes multiple myeloma cell adhesion and drug resistance through interactions with heparan sulfate proteoglycans.

bioRxiv · Sep 29, 2020Cancer Biology

Infection and transmission of SARS-CoV-2 depends on heparan sulfate proteoglycans

M. Bermejo-Jambrina, J. Eder, T. M. Kaptein, J. L. van Hamme, L. C. Helgers, K. E. Vlaming, P. J. Brouwer, A. P. Vlaar, F. E. H. P. van Baarle, M. Spaargaren, G. J. de Bree, B. M. Nijmeijer, N. A. Kootstra, M. J. van Gils, R. W. Sanders, T. B. H. Geijtenbeek

This study identifies heparan sulfate proteoglycans as SARS-CoV-2 attachment receptors and shows that LMWH blocks infection and transmission.

bioRxiv · Aug 18, 2020Immunology

Targeting AKT elicits tumor suppressive functions of FOXO transcription factors and GSK3 kinase in Multiple Myeloma

T. A. Bloedjes, G. de Wilde, C. Maas, E. E. Eldering, R. J. Bende, C. J. van Noesel, S. T. Pals, M. Spaargaren, J. E. Guikema

This study shows that AKT inhibition in multiple myeloma activates FOXO and GSK3, leading to MCL1 reduction and cell death, suggesting potential for combination therapies.

bioRxiv · Oct 24, 2019Cancer Biology