ATG5 selectively engages virus-tethered BST2/Tetherin in an LC3C-associated pathway
D. Judith, M. Versapuech, F. Bejjani, M. Palaric, P. Verlhac, A. Kuster, L. Lepont, S. Gallois-Montbrun, K. Janvier, C. Berlioz-Torrent
This paper identifies a novel LC3C-associated pathway triggered by HIV-1 infection, where ATG5 interacts with phosphorylated and dimerized BST2 to mediate viral restriction.
bioRxiv · Jan 6, 2023Microbiology