Author

A. L. Creason

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:spatial transcriptomics· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

J. Goecks· 4 shared E. Demir· 3 shared G. B. Mills· 3 shared B. E. Johnson· 2 shared C. Watson· 2 shared H. S. Feiler· 2 shared J. Egger· 2 shared J. W. Gray· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

J. Goecks

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4 papers

Recent·Most cited

Imputing Single-Cell Protein Abundance in Multiplex Tissue Imaging

R. Kirchgaessner, C. Watson, A. L. Creason, K. Keutler, J. Goecks

This paper imputes single-cell protein abundance in multiplex tissue imaging data from a breast cancer cohort using machine learning, showing improved accuracy and biological relevance.

bioRxiv · Dec 5, 2023Cancer Biology

Longitudinal and multimodal auditing of tumor adaptation to CDK4/6 inhibitors in HR+ metastatic breast cancers

A. L. Creason, J. Egger, C. Watson, S. Sivagnanam, K. Chin, K. MacPherson, J.-R. Lin, Y.-A. Chen, B. E. Johnson, H. S. Feiler, D. Galipeau, N. E. Navin, E. Demir, Y. H. Chang, C. L. Corless, , J. Goecks

This study creates a multimodal tumor atlas to analyze how metastatic HR+ breast cancers adapt to CDK4/6 inhibitors, revealing mechanisms like mTORC1 activation and immune microenvironment changes.

bioRxiv · Sep 27, 2023 · PreprintCancer Biology

Ongoing Replication Stress Response and New Clonal T Cell Development Discriminate Between Liver and Lung Recurrence Sites and Patient Outcomes in Pancreatic Ductal Adenocarcinoma

J. M. Link, C. Pelz, P. J. Worth, S. Owen, D. Keith, E. M. Langer, A. Grossblatt-Wait, A. L. Creason, J. Egger, H. Holly, I. English, K. MacPherson, M. Tsuda, J. Goecks, E. Demir, , R. C. Sears

This study identifies transcriptomic and immune features distinguishing liver and lung metastatic sites in PDAC, linking replication stress response and T cell clonal development to patient outcomes.

bioRxiv · May 4, 2022 · PreprintCancer Biology

An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer

B. E. Johnson, A. L. Creason, J. M. Stommel, J. M. Keck, S. Parmar, C. B. Betts, A. Blucher, C. Boniface, E. Bucher, E. A. Burlingame, T. Camp, K. Chin, J. Eng, J. Estabrook, H. S. Feiler, , J. W. Gray

This paper presents an OMS Atlas from serial biopsies of a metastatic breast cancer patient, linking clinical data to multi-omic and spatial profiles to study therapy-associated heterogeneity and resistance mechanisms.

bioRxiv · Dec 3, 2020Cancer Biology