R. C. Sears

Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer

The paper shows that metaplastic tuft cells in pancreatic cancer transdifferentiate into neural-like progenitor cells, driven by Myc activity, and this transition is linked to poor patient survival.

KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development

This study shows that KRASG12D upregulates CIP2A, which inhibits PP2A-B56α, leading to c-MYC stabilization and promoting pancreatic cancer initiation.

Robust biomarker discovery through multiplatform multiplex image analysis of breast cancer clinical cohorts

The paper identifies prognostic spatial biomarkers in breast cancer by analyzing multiple clinical cohorts using three multiplex imaging technologies.

A Novel Mouse Model that Recapitulates the Heterogeneity of Human Triple Negative Breast Cancer

This paper develops a novel mouse model of TNBC by combining MYC amplification and PTEN deletion, showing it recapitulates human TNBC heterogeneity through omic analyses.

Ongoing Replication Stress Response and New Clonal T Cell Development Discriminate Between Liver and Lung Recurrence Sites and Patient Outcomes in Pancreatic Ductal Adenocarcinoma

This study identifies transcriptomic and immune features distinguishing liver and lung metastatic sites in PDAC, linking replication stress response and T cell clonal development to patient outcomes.

Sulfopin, a selective covalent inhibitor of Pin1, blocks Myc-driven tumor initiation and growth in vivo

Sulfopin, a selective Pin1 inhibitor, reduces tumor initiation and growth in neuroblastoma models by targeting c-Myc pathways.

Acidic fibroblast growth factor underlies microenvironmental regulation of MYC in pancreatic cancer

This study identifies FGF1 from cancer-associated fibroblasts as a paracrine regulator of MYC in pancreatic cancer, showing its role in MYC stability and tumor formation.