Author

A. L. Goldberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

A. K. Mittermaier· 1 shared B. Pan· 1 shared E. Rennella· 1 shared H. Zhang· 1 shared J. B. Juravsky· 1 shared J. L. Rubinstein· 1 shared L. E. Kay· 1 shared M. D. Rekhter· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. K. Mittermaier

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2 papers

Recent·Most cited

An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR

S. Vahidi, Z. A. Ripstein, J. B. Juravsky, E. Rennella, A. L. Goldberg, A. K. Mittermaier, J. L. Rubinstein, L. E. Kay

This paper identifies an allosteric switch in Mycobacterium tuberculosis ClpP1P2 protease that regulates its activity through conformational changes, revealed by cryo-EM and methyl-TROSY NMR.

Proceedings of the National Academy of Sciences · Mar 2, 2020Peer-reviewedBiophysics

Duo-activation of PKA and PKG by PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against proteinopathy

H. Zhang, B. Pan, M. D. Rekhter, A. L. Goldberg, X. Wang

PDE1 inhibition enhances proteasomal degradation of misfolded proteins via PKA and PKG activation, reducing cardiac proteinopathy and HFpEF in CryABR120G mice.

bioRxiv · Feb 7, 2019Cell Biology