Duo-activation of PKA and PKG by PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against proteinopathy
H. Zhang, B. Pan, M. D. Rekhter, A. L. Goldberg, X. Wang
PDE1 inhibition enhances proteasomal degradation of misfolded proteins via PKA and PKG activation, reducing cardiac proteinopathy and HFpEF in CryABR120G mice.
bioRxiv · Feb 7, 2019Cell Biology