A tug-of-war between the NuRD and SWI/SNF chromatin remodelers regulates the coordinated activation of Epithelial-Mesenchymal Transition and inflammation in oral cancer.
R. Stabile, F. A. Tucci, M. P. Verhagen, C. Embregts, T. P. P. Van denBosh, R. Joosten, M. J. de HErdt, B. van der Steen, A. L. Nigg, S. Koljenovic, J. A. Hardillo, C. P. Verrijzer, A. Biddle, R. J. Baatenburg de Jong, P. J. Leenen, R. Fodde
The paper shows that competition between NuRD and SWI/SNF chromatin remodelers regulates epithelial-mesenchymal plasticity and inflammation in oral cancer, with CDK2AP1 loss promoting pro-inflammatory responses and macrophage recruitment.
bioRxiv · Apr 5, 2024 · PreprintCancer Biology