Nuclear GSK-3β and Oncogenic KRas Promote Expansion of Terminal Duct Cells and the Development of Intraductal Papillary Mucinous Neoplasm
L. Ding, K. Roeck, C. Zhang, B. Zidek, E. Rodman, Y. G. Hernandez-Barco, J.-S. Zhang, W. R. Bamlet, A. L. Oberg, L. Zhang, N. Bardeesy, H. Li, D. D. Billadeau
This study identifies Aqp5 as a key factor in IPMN development using a novel mouse model, linking nuclear GSK-3β and oncogenic KRas to terminal duct cell expansion.
bioRxiv · Jul 14, 2020 · PreprintCancer Biology