Author

D. D. Billadeau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

B. Chen· 3 shared D. A. Kramer· 3 shared A. Singla· 2 shared D. J. Boesch· 2 shared E. Burstein· 2 shared L. Ding· 2 shared P. Juneja· 2 shared Y. Han· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

B. Chen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural basis for Retriever-SNX17 assembly and endosomal sorting

A. Singla, D. J. Boesch, H. Y. J. Fung, C. Ngoka, A. S. Enriquez, R. Song, D. A. Kramer, Y. Han, P. Juneja, D. D. Billadeau, X. Bai, Z. Chen, E. E. Turer, E. Burstein, B. Chen

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

bioRxiv · Mar 12, 2024Biochemistry

Structural Organization of the Retriever-CCC Endosomal Recycling Complex

D. J. Boesch, A. Singla, Y. Han, D. A. Kramer, Q. Liu, K. Suzuki, P. Juneja, X. Zhao, X. Long, M. J. Medlyn, D. D. Billadeau, Z. Chen, B. Chen, E. Burstein

This study determines the high-resolution structure of the Retriever-CCC endosomal recycling complex using cryo-EM and reveals how cancer mutations disrupt its function.

bioRxiv · Jun 6, 2023Cell Biology

Arf GTPase activates the WAVE Regulatory Complex through a novel binding site

S. Yang, Y. Liu, A. Brown, M. Schaks, B. Ding, D. A. Kramer, L. Ding, O. Alekhina, D. D. Billadeau, S. Chowdhury, J. Wang, K. Rottner, B. Chen

This study identifies a novel Arf1 binding site on WRC that drives activation through a mechanism distinct from Rac1.

bioRxiv · May 13, 2022 · PreprintBiochemistry

Nuclear GSK-3β and Oncogenic KRas Promote Expansion of Terminal Duct Cells and the Development of Intraductal Papillary Mucinous Neoplasm

L. Ding, K. Roeck, C. Zhang, B. Zidek, E. Rodman, Y. G. Hernandez-Barco, J.-S. Zhang, W. R. Bamlet, A. L. Oberg, L. Zhang, N. Bardeesy, H. Li, D. D. Billadeau

This study identifies Aqp5 as a key factor in IPMN development using a novel mouse model, linking nuclear GSK-3β and oncogenic KRas to terminal duct cell expansion.

bioRxiv · Jul 14, 2020 · PreprintCancer Biology