Ferric Heme as a CO/NO Sensor in the Nuclear Receptor Reverbβ by Coupling Gas binding to Electron Transfer
S. W. Ragsdale, A. Sarkar, E. L. Carter, J. B. Harland, A. L. Speelman, N. Lehnert
This study shows that Rev-Erbβ functions as a CO/NO sensor by coupling gas binding to electron transfer, maintaining Fe3+ heme state for repressor activity and enabling redox changes upon gas binding.
bioRxiv · Jun 22, 2020Biochemistry